Treatment protocols
Compare prescription and herbal approaches side by side. Each protocol lists its components, typical doses, key points and original source.
Clarithromycin + Tinidazole + Liposomal Essential Oils
Macrolide + azole + herbal persister coverage
- Clarithromycin
- Tinidazole
- Liposomal cinnamon, clove & oregano oil
High-Dose Amoxicillin + Pulsed Tinidazole + Essential Oils
An oral alternative Dr. Ross considers nearly IV-strength
- Amoxicillin
- Tinidazole
- Liposomal cinnamon, clove & oregano oil
Ross Herbal Combination 1: Banderol + Samento + Cryptolepis
All-herbal regimen Dr. Ross finds as effective as oral antibiotics
- Banderol
- Samento
- Cryptolepis
Ross Herbal Combination 2: Cat's Claw + Japanese Knotweed + Essential Oils
Three herbs each shown in the lab to kill growing and persister Lyme
- Cat's claw
- Japanese knotweed
- Liposomal cinnamon, clove & oregano oil
Buhner Core Protocol
Stephen Harrod Buhner's herbal approach from Healing Lyme
- Japanese knotweed
- Cat's claw
- Andrographis
- Sida acuta
- +1 more
Horowitz Dapsone Combination Therapy
Dr. Richard Horowitz's persister protocol (DDDCT / HDDCT)
- Cefuroxime
- Minocycline
- Rifampin
- Dapsone
Foundation & Herx Support
Gut, detox, sleep and liver support to use alongside any protocol
- Saccharomyces boulardii
- Multi-strain probiotic
- Activated charcoal or other binder
- NAC or liposomal glutathione
- +2 more
Azithromycin + Plaquenil + Metronidazole + Methylene Blue
Macrolide boosted by hydroxychloroquine, with a persister drug
- Azithromycin
- Hydroxychloroquine
- Metronidazole
- Methylene blue
Clarithromycin + Grapefruit Seed Extract + Cryptolepis
A gentler anti-cyst option that also covers Babesia
- Clarithromycin
- Grapefruit seed extract
- Cryptolepis
Doxycycline + Clarithromycin + GSE + Japanese Knotweed
Double ribosome blockade with herbal persister support
- Doxycycline
- Clarithromycin
- Grapefruit seed extract
- Japanese knotweed
Cowden Support Program
Dr. Lee Cowden's structured 9-month Nutramedix protocol
- Burbur-Pinella
- Samento
- Cumanda
- Banderol
- +2 more
Zhang Protocol (Chinese Herbal Medicine)
Dr. Qingcai Zhang's integrative Chinese-herbal approach
- Allicin
- Coptis
- HH
- Artemisinin
- +2 more
Byron White Formulas
Low-dose, slow-build herbal formulas for Lyme and co-infections
- A-L Complex
- A-Bart
- A-Bab
- Detox / drainage formula
Dr. Bill Rawls / Vital Plan Approach
Rotating herbal antimicrobials plus adaptogens and lifestyle
- Andrographis
- Japanese knotweed
- Cat's claw
- Garlic
- +2 more
Minocycline + Rifampin + Disulfiram
Covers growing Lyme, Bartonella, and Lyme persisters
- Minocycline
- Rifampin
- Disulfiram
Disulfiram (Antabuse) Monotherapy
A repurposed alcoholism drug for long-term treatment failures
- Disulfiram
IV Ceftriaxone + Pulsed Tinidazole + Essential Oils
A simple, lower-cost IV regimen
- Ceftriaxone
- Tinidazole
- Liposomal cinnamon, clove & oregano oil
Bicillin LA Injections
Intramuscular penicillin as an IV-equivalent option
- Bicillin LA
Biofilm Busting Add-Ons
Agents used to break down the protective layers that shelter bacteria
- Serrapeptase
- Lumbrokinase
- N-acetyl cysteine
- Cistus incanus tea
Artemisinin + Cistus Protocol
A low-cost community protocol: biofilm tea, pulsed artemisinin and detox
- Cistus incanus tea
- Artemisinin
- Water
- Psyllium husk
- +2 more
Artemisia + Cistus Tea Protocol for Kids
A gentle, tea-based version of the Artemisinin + Cistus protocol for children
- Artemisia annua leaf
- Cistus incanus
| Protocol | Type | Components | Targets | Intensity | Rx |
|---|---|---|---|---|---|
| Clarithromycin + Tinidazole + Liposomal Essential Oils | Antibiotic | Clarithromycin · Tinidazole · Liposomal cinnamon, clove & oregano oil | Lyme | Moderate | Yes |
| High-Dose Amoxicillin + Pulsed Tinidazole + Essential Oils | Antibiotic | Amoxicillin · Tinidazole · Liposomal cinnamon, clove & oregano oil | Lyme | Moderate | Yes |
| Ross Herbal Combination 1: Banderol + Samento + Cryptolepis | Herbal | Banderol · Samento · Cryptolepis | LymeBabesia | Moderate | No |
| Ross Herbal Combination 2: Cat's Claw + Japanese Knotweed + Essential Oils | Herbal | Cat's claw · Japanese knotweed · Liposomal cinnamon, clove & oregano oil | LymeBartonella | Gentle | No |
| Buhner Core Protocol | Herbal | Japanese knotweed · Cat's claw · Andrographis · Sida acuta · Houttuynia | LymeBartonellaBabesia | Moderate | No |
| Horowitz Dapsone Combination Therapy | Persister | Cefuroxime · Minocycline · Rifampin · Dapsone | LymeBartonellaBabesia | Intensive | Yes |
| Foundation & Herx Support | Foundation & Support | Saccharomyces boulardii · Multi-strain probiotic · Activated charcoal or other binder · NAC or liposomal glutathione · Magnesium glycinate · Omega-3 fish oil | LymeBartonellaBabesiaOther co-infections | Gentle | No |
| Azithromycin + Plaquenil + Metronidazole + Methylene Blue | Antibiotic | Azithromycin · Hydroxychloroquine · Metronidazole · Methylene blue | Lyme | Intensive | Yes |
| Clarithromycin + Grapefruit Seed Extract + Cryptolepis | Antibiotic | Clarithromycin · Grapefruit seed extract · Cryptolepis | LymeBabesia | Moderate | Yes |
| Doxycycline + Clarithromycin + GSE + Japanese Knotweed | Antibiotic | Doxycycline · Clarithromycin · Grapefruit seed extract · Japanese knotweed | Lyme | Intensive | Yes |
| Cowden Support Program | Herbal | Burbur-Pinella · Samento · Cumanda · Banderol · Serrapeptase · Magnesium | LymeBartonellaBabesia | Moderate | No |
| Zhang Protocol (Chinese Herbal Medicine) | Herbal | Allicin · Coptis · HH · Artemisinin · Circulation P · AI #3 | LymeBabesia | Moderate | No |
| Byron White Formulas | Herbal | A-L Complex · A-Bart · A-Bab · Detox / drainage formula | LymeBartonellaBabesia | Gentle | No |
| Dr. Bill Rawls / Vital Plan Approach | Herbal | Andrographis · Japanese knotweed · Cat's claw · Garlic · Cryptolepis · Reishi | LymeBartonellaBabesia | Gentle | No |
| Minocycline + Rifampin + Disulfiram | Persister | Minocycline · Rifampin · Disulfiram | LymeBartonella | Intensive | Yes |
| Disulfiram (Antabuse) Monotherapy | Persister | Disulfiram | Lyme | Intensive | Yes |
| IV Ceftriaxone + Pulsed Tinidazole + Essential Oils | IV / Injectable | Ceftriaxone · Tinidazole · Liposomal cinnamon, clove & oregano oil | Lyme | Intensive | Yes |
| Bicillin LA Injections | IV / Injectable | Bicillin LA | Lyme | Moderate | Yes |
| Biofilm Busting Add-Ons | Foundation & Support | Serrapeptase · Lumbrokinase · N-acetyl cysteine · Cistus incanus tea | LymeBartonellaBabesia | Gentle | No |
| Artemisinin + Cistus Protocol | Herbal | Cistus incanus tea · Artemisinin · Water · Psyllium husk · Hot Epsom salt bath · Binder | LymeBabesiaBartonella | Moderate | No |
| Artemisia + Cistus Tea Protocol for Kids | Herbal | Artemisia annua leaf · Cistus incanus | LymeBabesiaBartonella | Gentle | No |
Read before you start. Doses shown are adult doses as published by the original source and are listed for education. Prescription regimens require a doctor and lab monitoring. Herbs can interact with medications. Always work with a qualified clinician.