Bicillin LA Injections
Intramuscular penicillin as an IV-equivalent option
- Targets
- Lyme
- Intensity
- Moderate
- Components
- 1
- Prescription
- Required
Long-acting benzathine penicillin G given as an intramuscular injection. Dr. Ross considers it nearly as effective as IV antibiotics, without the need for an IV line. Combine with intracellular and anti-cyst agents.
The regimen
Duration: Ongoing, typically several injections per week
Key points
- No IV line required
- Penicillin only works outside cells — pair with a macrolide or tetracycline
- Add a cyst agent (azole, rifamycin or GSE) and a persister agent
- Injections can be painful
Why this combination
Dr. Ross builds every regimen around four rules: cover all forms of the germ (spirochetes and round-body cysts), cover Lyme inside and outside cells, combine drugs that attack in different ways, and hit growing and persister phases at the same time.
He stresses that antibiotics alone are rarely enough — immune, sleep, gut and detox support (see Foundation & Herx Support) are essential to reach the success rates he reports.
Discussion
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Not medical advice. This protocol is summarized from Dr. Marty Ross, MD — A Lyme Disease Antibiotic Guide for educational purposes. Doses are for adults; children need different dosing. Discuss any treatment with a qualified, Lyme-literate clinician, who can monitor labs and adjust for your health and medications.