Minocycline + Rifampin + Disulfiram
Covers growing Lyme, Bartonella, and Lyme persisters
- Targets
- Lyme, Bartonella
- Intensity
- Intensive
- Components
- 3
- Prescription
- Required
Minocycline and rifampin treat growing Lyme and a Bartonella co-infection; disulfiram is added specifically for Lyme persisters. Disulfiram does not appear to treat Bartonella.
The regimen
Duration: Disulfiram built up over 2–4 months, held 4 months at peak, then tapered
Key points
- Choosing drugs that cover Lyme and a co-infection at the same time simplifies treatment
- Disulfiram requires strict avoidance of all alcohol — including tinctures, mouthwash and some sauces
- Rifampin requires liver monitoring (many LLMDs test on day 2, 7, 14, then monthly)
- Rifampin interacts with many medications, including birth control
Why this combination
Dr. Ross builds every regimen around four rules: cover all forms of the germ (spirochetes and round-body cysts), cover Lyme inside and outside cells, combine drugs that attack in different ways, and hit growing and persister phases at the same time.
He stresses that antibiotics alone are rarely enough — immune, sleep, gut and detox support (see Foundation & Herx Support) are essential to reach the success rates he reports.
Discussion
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Not medical advice. This protocol is summarized from Dr. Marty Ross, MD — A Lyme Disease Antibiotic Guide for educational purposes. Doses are for adults; children need different dosing. Discuss any treatment with a qualified, Lyme-literate clinician, who can monitor labs and adjust for your health and medications.